Paradoxical Dampening of Anti-Islet Self-Reactivity but Promotion of Diabetes by OX40 Ligand
نویسندگان
چکیده
منابع مشابه
Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand.
Costimulatory signals received by diabetogenic T cells during priming by or upon secondary encounter with autoantigen are decisive in determining the outcome of autoimmune attack. The OX40-OX40 ligand (OX40L) costimulatory pathway is known to influence T cell responses, prompting us to examine its role in autoimmune diabetes. A null allele at OX40L completely prevented diabetes development in n...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2003
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.171.12.6954